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Simparica TRIO for Dogs 11.1-22 lbs (Caramel)

310 customer reviews

Simparica TRIO for Dogs 11.1-22 lbs (Caramel)

$134.37 $95.98

  • $134.37 $95.98
  • $244.97 $174.98
  • $465.47 $332.48
  • Simparica Trio Caramel is suitable for dogs weighing between 11.1-22.0lbs
  • Offers broad-spectrum protection
  • Provides flexible dosing options (12mg sarolaner, 0.24mg moxidectin, & 50mg pyrantel)
  • Aids in the treatment of both external and internal parasites
  • Protects against five different species of ticks
  • Available in 3, 6 and 12 doses pack sizes
  • Information
  • Features
  • How to Use
  • Safety
  • Simparica TRIO Ingredients
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Simparica Trio Caramel for 11.1-22 lbs Dogs

Simparica Trio Caramel for dogs is a highly palatable, multi-spectrum treatment that protects against both external and internal parasites. This flavoured, monthly chewable formula is recommended for use in 8 weeks and older puppies and dogs that weigh 2.8 lbs or more.

Simparica Trio (11.1–22.0 lbs) prevents heartworm infection, treats and controls roundworms, and hookworm infections. It kills adult fleas, and treats and prevents flea infections. This monthly formula treats and controls lone star ticks, Gulf coast ticks, American dog ticks, black-legged ticks, and brown dog ticks. Simparica Trio belongs to the isoxazoline class and it is highly recommended to use this treatment with caution on dogs with seizures or other neurologic disorders. The safe use of Simparica Trio in breeding, pregnant or lactating dogs has not been evaluated.

Simparica Trio (sarolaner, moxidectin, and pyrantel) All-in-one Treatment for Dogs

Simparica Trio caramel pack is a blend of three premium ingredients (sarolaner:12mg, moxidectin: 0.24mg, and pyrantel:50mg) precisely designed for 11.1-22.0 lbs dogs. The trio formula (sarolaner, moxidectin, and pyrantel) starts working immediately after administration. Sarolaner works at neuromuscular junctions in parasites causing uncontrolled activity and death in the end. Moxidectin interfers with chloride channel mediated neurotransmission in parasites and cause death. Pyrantel works as a neuromuscular blocking agent resulting in paralysis of the insect causing death. A single dose of Simparica Trio kills fleas, ticks, prevents heartworms, kills deer ticks, and prevents Lyme disease, and treats and controls roundworm and hookworm infections.


  • Three-in-one treatment for dogs
  • Palatable liver-flavored chews
  • Protects dogs from fleas and ticks
  • Aids in monthly heartworm prevention
  • Effective against as many as 5 tick species

How to Use

  • Pick the appropriate pack based on the weight of your dog.
  • One oral chew should be directly administered into the dog’s mouth.
  • It can also be mixed with the pet’s meal.
  • Repeat dosage once every month for better results.
  • For further assistance, kindly refer to product pack.


  • Suitable for puppies and dogs over 8 weeks of age.
  • Keep chews out of the reach of children.
  • Wash hands thoroughly after administering.
  • Store oral treatment in a dry and cool place.
  • Treatment is only meant for dogs.


Warnings and Precautions

  • Use with caution for dogs that have a history of seizure attacks, tremors, ataxia, etc.
  • The safe use of this treatment on pregnant, lactating, and breeding dogs has not yet be evaluated.

Simparica TRIO Ingredients

Sarolaner, Moxidectin, and Pyrantel

Simparica TRIO Reviews (310)

Product Rated 4.7/5 (310 customer reviews)
Lisa Lichtig – June 12, 2024

My 5 lb dog is on this for flea and tick plus heartworm protection. It’s effective protection and my dog consumes one pill wrapped in melted cheese each month. I’ve tried two other edibles that my pup wouldn’t consume prior to this. This is one of the more affordable places to refill the rx!.

Carol Sanabria – June 10, 2024

Definitely does the job!… I hide the pill in a pill pocket and without a problem down the hatch. No signs of Fleas/Ticks or worms . Definitely recommend!!.

Nancy Plocharczyk – June 06, 2024
Simperica trio

Good value.

Mattie – June 05, 2024
Great performance

Super effective product. I am completely satisfied with the performance..

Lisa Beverly – May 31, 2024
Flea and tick meds

Love the price, the convenience and delivery time.

Elizabeth Spraus – May 31, 2024
Fast shipping

Item came in on time and exactly as seen.

Sophia – May 30, 2024
Triple effect

This one product is enough to remove fleas and ticks and protect my pet from heartworms. Nice option..

Kenneth Wells – May 29, 2024
Very cheap and good meds

I always order from them for the last 5 years. Alot cheaper than store or vet.

Victor Gifford – May 22, 2024
Animal care

Great product, good price and good customer service. I will definitely order from them again..

Nick Reese – May 18, 2024
Excellent !!!!

it really works and fast and my dog likes taking it.