1-800-797-5305

CALL US NOW: 1-800-797-5305

Your cart

You have no products in your cart.

Earn Reward Points & Get 20% OFF On Your Order, Use Coupon CELBFD20 - Free Shipping On All Orders!

Simparica TRIO for Dogs

(455 customer reviews)
Pack
Qty
You Pay
3 DOSES
$43.01
6 DOSES
$80.25
Pack
Qty
You Pay
3 DOSES
$43.99
6 DOSES
$81.23
12 DOSES
$156.69
Pack
Qty
You Pay
3 DOSES
$52.81
6 DOSES
$91.03
12 DOSES
$176.29
Pack
Qty
You Pay
3 DOSES
$54.77
6 DOSES
$99.85
12 DOSES
$191.97
Pack
Qty
You Pay
3 DOSES
$56.73
6 DOSES
$101.81
12 DOSES
$194.91
Pack
Qty
You Pay
3 DOSES
$58.69
6 DOSES
$105.73
12 DOSES
$205.69
highlights
  • Made with an advance three-in-one formula
  • Kills adult fleas and prevents future flea infestations
  • Protects against five different types of ticks
  • Eliminates Deer Ticks, Gulf Coast Ticks, Brown Dog Ticks, Lone Star Ticks, and Deer Ticks
  • Prevents heartworm disease
  • Block infections that may cause Lyme disease
  • Kills roundworms and hookworms
  • Easy-to-give, palatable, flavored chewable
  • Safe for use in 8 weeks and older puppies and dogs
  • Information
  • Features
  • How to Use
  • Safety
  • Simparica TRIO Ingredients
Information
tab article

Simparica Trio flea, Tick & Heartworm

What is Simparica Trio for Dogs

Simparica Trio is an advanced three-in-one treatment for dogs. This liver-flavored treatment is effective against worms, ticks, and fleas. It protects dogs from as many as five tick species - gulf coast ticks, American dog ticks, Lone star ticks, deer ticks, and Brown dog ticks. Besides, it kills fleas within 4 hours and manages to eliminate them before they can lay eggs. Moreover, Simparica Trio is recommended for the use in puppies and dogs over the age of 8 weeks.

Simparica Trio: One Chew, Triple Protection

Simparica Trio for dogs is a multi-spectrum, palatable formula that protects 8 weeks and older dogs against both external and internal parasites for one month. The trio formula provides three-way protection, which means, it

Prevents Deadly Heartworm Disease Heartworm disease can be fatal for canines. Heartworm infected dogs do not show ill symptoms right away. In fact, it takes months for them to get detected even with laboratory investigations. Monthly administration of Simparica Trio Chewable effectively prevents heartworm infection and keeps your dog protected.

Terminates Fleas Simparica Trio kills adult fleas. The oral formula kills fleas before they can lay eggs; hence it is useful for the treatment and prevention of flea infestations.

Kills Five Types of Ticks Simparica Trio is lethal against ticks. It is approved to kill five different types of ticks including Gulf Coast Ticks, Deer Ticks, Brown Dog Ticks, Lone Star Ticks, and American Dog Ticks.

Prevents Lyme Disease Simparica Trio kills black-legged ticks (Deer ticks) and blocks the parasites that may cause Lyme disease.

Roundworms and Hookworms are Harmful Simparica Trio for dogs is recommended for the treatment of intestinal worms including hookworms and roundworms. Monthly administration of Simparica Trio controls any future infestations..

How Does Simparica Trio for Dogs Work? Simparica Trio for Dogs comes with a triple action formula that provides three-way protection. This chewable treatment is composed of three high-quality ingredients including

Sarolaner works as an 'ectoparasiticide' which means it kills the parasites such as fleas and ticks that live on the dog's body (on fur and skin) and feed on their blood. Sarolaner kills parasites by acting on their nervous system causing uncontrolled activity resulting in paralysis of the parasites and insect death in the end.

Moxidectin works on internal parasites that live inside dog's body including heartworms, roundworms, and hookworms. This ingredient interferes with the chloride ions' flow in nerve cells connected with GABA and glutamate, causing paralysis and death of the parasites.

Pyrantel kills gastrointestinal worms including roundworms and hookworms, by blocking the neurotransmitter signals. This causes instant contractions resulting in paralysis and death.

Features
Benefits

  • Three-in-one treatment for dogs
  • Palatable liver-flavored chews
  • Protects dogs from fleas and ticks
  • Aids in monthly heartworm prevention
  • Effective against as many as 5 tick species

How to Use
Directions

  • Pick the appropriate pack based on the weight of your dog.
  • One oral chew should be directly administered into the dog’s mouth.
  • It can also be mixed with the pet’s meal.
  • Repeat dosage once every month for better results.
  • For further assistance, kindly refer to product pack.

Safety
Safety

  • Suitable for puppies and dogs over 8 weeks of age.
  • Keep chews out of the reach of children.
  • Wash hands thoroughly after administering.
  • Store oral treatment in a dry and cool place.
  • Treatment is only meant for dogs.

 

Warnings and Precautions

  • Use with caution for dogs that have a history of seizure attacks, tremors, ataxia, etc.
  • The safe use of this treatment on pregnant, lactating, and breeding dogs has not yet be evaluated.

Simparica TRIO Ingredients
Ingredients

Sarolaner, Moxidectin, and Pyrantel

Simparica TRIO Reviews (455)

Product Rated 4.8/5 (455 customer reviews)
June – June 08, 2025
Tasty chews

It is hardly a treatment for my pet. She enjoys it like a treat..

Terry Lee – June 07, 2025
Lexi....Husky

Great medication....only med for her monthly.

Nancy ANGSTADT – June 07, 2025
Simparica Trio

Great price and fast delivery!.

Cynthia Ziaja Messick – June 05, 2025
Have been using this product for 4 years for my dogs from budget vet care.

The product protects them against heartworm, fleas, ticks and other worms. Have had no problems purchasing from Budget Vet Care at a reduced price. Arrived in about 2 weeks.

Amy Kennedy – June 05, 2025
Meds

Meds.

Amanda Starling – June 03, 2025
Awesome

Great prices.

Hillary – June 02, 2025
Wide coverage

A single product to remove various types of parasites. Very nice solution..

melinda miller – May 29, 2025
Simpirca

Always competitive and excellent customer service thx u.

Kimberly Allen – May 28, 2025
Expwrience

Great experience from ordering to delivery!.

Donald – May 24, 2025
Nice flavor

Dosing takes hardly any effort. My pet loves its taste..