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Simparica TRIO for Dogs 11.1-22 lbs (Caramel)

258 customer reviews

Simparica TRIO for Dogs 11.1-22 lbs (Caramel)

$134.37 $95.98

  • $134.37 $95.98
  • $244.97 $174.98
  • $465.47 $332.48
  • Simparica Trio Caramel is suitable for dogs weighing between 11.1-22.0lbs
  • Offers broad-spectrum protection
  • Provides flexible dosing options (12mg sarolaner, 0.24mg moxidectin, & 50mg pyrantel)
  • Aids in the treatment of both external and internal parasites
  • Protects against five different species of ticks
  • Available in 3, 6 and 12 doses pack sizes
  • Information
  • Features
  • How to Use
  • Safety
  • Simparica TRIO Ingredients
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Simparica Trio Caramel for 11.1-22 lbs Dogs

Simparica Trio Caramel for dogs is a highly palatable, multi-spectrum treatment that protects against both external and internal parasites. This flavoured, monthly chewable formula is recommended for use in 8 weeks and older puppies and dogs that weigh 2.8 lbs or more.

Simparica Trio (11.1–22.0 lbs) prevents heartworm infection, treats and controls roundworms, and hookworm infections. It kills adult fleas, and treats and prevents flea infections. This monthly formula treats and controls lone star ticks, Gulf coast ticks, American dog ticks, black-legged ticks, and brown dog ticks. Simparica Trio belongs to the isoxazoline class and it is highly recommended to use this treatment with caution on dogs with seizures or other neurologic disorders. The safe use of Simparica Trio in breeding, pregnant or lactating dogs has not been evaluated.

Simparica Trio (sarolaner, moxidectin, and pyrantel) All-in-one Treatment for Dogs

Simparica Trio caramel pack is a blend of three premium ingredients (sarolaner:12mg, moxidectin: 0.24mg, and pyrantel:50mg) precisely designed for 11.1-22.0 lbs dogs. The trio formula (sarolaner, moxidectin, and pyrantel) starts working immediately after administration. Sarolaner works at neuromuscular junctions in parasites causing uncontrolled activity and death in the end. Moxidectin interfers with chloride channel mediated neurotransmission in parasites and cause death. Pyrantel works as a neuromuscular blocking agent resulting in paralysis of the insect causing death. A single dose of Simparica Trio kills fleas, ticks, prevents heartworms, kills deer ticks, and prevents Lyme disease, and treats and controls roundworm and hookworm infections.


  • Three-in-one treatment for dogs
  • Palatable liver-flavored chews
  • Protects dogs from fleas and ticks
  • Aids in monthly heartworm prevention
  • Effective against as many as 5 tick species

How to Use

  • Pick the appropriate pack based on the weight of your dog.
  • One oral chew should be directly administered into the dog’s mouth.
  • It can also be mixed with the pet’s meal.
  • Repeat dosage once every month for better results.
  • For further assistance, kindly refer to product pack.


  • Suitable for puppies and dogs over 8 weeks of age.
  • Keep chews out of the reach of children.
  • Wash hands thoroughly after administering.
  • Store oral treatment in a dry and cool place.
  • Treatment is only meant for dogs.


Warnings and Precautions

  • Use with caution for dogs that have a history of seizure attacks, tremors, ataxia, etc.
  • The safe use of this treatment on pregnant, lactating, and breeding dogs has not yet be evaluated.

Simparica TRIO Ingredients

Sarolaner, Moxidectin, and Pyrantel

Simparica TRIO Reviews (258)

Product Rated 4.7/5 (258 customer reviews)
Shelley Krug – February 15, 2024
Great price

Could not beat this price anywhere.

Don Schminkey – February 13, 2024
Simparica Trio for dogs

Fast shipping and great price. Will buy again.

Cheryl Eddy – February 07, 2024

This is the first US FDA certified flea tick and heart worm prevention. It also works on other parasites. My dog eats them like a treat with no hesitation. He’s never been ill I’ve only used this product since he was 10 weeks old. The medication was shipped quickly and arrived OK. I have checked lot numbers and expiry dates with ZOETIS and they are legitimate..

LORY SCHULZ – January 29, 2024
Simparica Trio

Always has the best prices to help our fur babies.

Caden – January 25, 2024
Best Pricing

Got all my pet essentials at incredibly lowest prices..

Brooks – January 18, 2024
Great care

Works for all the common range of parasites without any fuss.

Sandy Mesnard – January 15, 2024
Simparica Trio

Great price and prompt shipper. Will definitely buy again!.

maria dalstrom – January 09, 2024
Simpatico trio

Love budget vet care. We have not started this product yet..

Jasper – January 09, 2024
Wonderful Protection

Protects my furry friend against rangeof common parasites without any discomfort.

Barbara Vazquez – January 07, 2024
Wonderful company

This is really a good company. We are glad we found them. Happy new year..