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Comfortis Plus
Fleas Heartworm Worms

Comfortis Plus (Trifexis) for Dog

(127 customer reviews)
You Pay
6 Chews
12 Chews
You Pay
6 Chews
12 Chews
You Pay
6 Chews
12 Chews
You Pay
6 Chews
12 Chews
You Pay
6 Chews
12 Chews
  • All-in-one treatment for fleas, worms, and heartworms in dogs
  • Easy-to-dose highly-palatable tablet
  • Once-a-month administration
  • Kills 100% fleas within 24 hours and prevents further infestations
  • Treats flea allergy dermatitis
  • Treats intestinal worms like hookworms, roundworms, and whipworms
  • Prevents deadly heartworm disease
  • Information
  • Features
  • How to Use
  • Safety
  • Comfortis Plus (Trifexis) Ingredients


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Comfortis Plus – Fleas, Worms, and Heartworm Protection

Comfortis Plus is an advanced formulation that provides 3-in-1 protection against fleas, worms, and heartworms in dogs. The monthly oral tablet controls heartworms and protects dogs against the deadly heartworm disease. It kills fleas within 24 hours and controls and prevents flea infestations. The oral tablet is also effective in treating intestinal worms, including hookworms, roundworms, and whipworms. Furthermore, Comfortis Plus also aids in the control of flea allergy dermatitis.

It is recommended for use in dogs and puppies from eight weeks of age weighing 5 lbs or greater.

How Dose Comfortis Plus for Dogs Work?

Comfortis Plus contains two active insecticides: Spinosad and Milbemycin Oxime. Spinosad is an effective insecticide with no negative effects on the environment. The ingredient acts on the nervous system of fleas, triggering their nerve cells. This leads to involuntary muscle contractions and tremors, which lead to the destruction of the fleas. It starts killing fleas within 30 minutes and eliminates 100% of them within 24 hours.

The other active ingredient, Milbemycin Oxime, attacks intestinal worms and immature forms of heartworms. The anthelmintic effectively controls heartworms and intestinal worms, protecting the dog from harmful infections.




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  • Advanced version of comfortis with added features
  • New age formula for effectively treating fleas and worms
  • Prevents and controls heartworm infection
  • Starts working on fleas within 30 minutes of administration
  • Treats and prevents worms including hookworm, roundworm, and whipworm
  • Helps in the prevention of flea infestation
  • Supports in the control program of flea allergy dermatitis

How to Use

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  • Dosage depends on dog weight.
  • Administer it directly into the mouth or mix it with food.
  • Ensure the dog finishes the whole food for complete dosage.


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  • Do not use in cats.
  • Keep out of reach of children and other pets.
  • Store it in a cool and dry place.
  • Avoid using on puppies less than 8 weeks of age.
  • Safety in pregnant and lactating dogs has not been evaluated yet.


  • No known side effects found yet.

Comfortis Plus (Trifexis) Ingredients

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  • Spinosad
  • Milbemycin Oxime

Comfortis Plus (Trifexis) Reviews (127)

Product Rated 4.6/5 (127 customer reviews)
Kate – June 03, 2023
Works for us

It worked for our by, i cannot see any fleas on her skin.

Mathew – May 28, 2023
Nice Product

quickly controls flea and ticks.

Jinney – May 21, 2023

My Dogs love its taste.

Jenny – May 13, 2023
Must try

an effective treatment against various parasites.

Jacky – May 07, 2023

a best treatment you can have for your pet.

Paul – April 30, 2023

A reliable solution for flea and ticks.

Russell Harmon – April 26, 2023
Great product

Since in Texas the fleas here have turned into super fleas. The drops doing work at all. Have to get them from the inside out. This covers everything. And if you treat your yard you can make this last longer..

Kathy Oliphant – April 26, 2023

Great product at a great price. Fast shipping. Good customer service!.

sandra skipper – April 21, 2023
Comfortis plus

Great value: treats fleas, and heart worms!.

Austin – April 21, 2023
Works wonder

My dog is much relived after the fleas are eradicated thans to comfortis plus.