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Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue

Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue

114 customer reviews

$123.12 $87.94

  • $123.12 $87.94
  • $242.10 $172.93

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Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue
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Buy Other Packs

Comfortis Plus (Trifexis) Chewable Tablets for XSmall Dogs 2.3-4.5kg (5 to 10lbs) Pink

$101.37 $72.41

Comfortis Plus (Trifexis) Chewable Tablets for Small Dogs 4.5-9 kg (10 to 20lbs) Orange

$105.49 $75.35

Comfortis Plus (Trifexis) Chewable Tablets for Medium Dogs 9-18 kg (20 to 40lbs) Green

$115.14 $82.24

Comfortis Plus (Trifexis) Chewable Tablets for Xlarge Dogs 27-54 kg (60 to 120lbs) Brown

$128.81 $92.01

Product Review

  • Comfortis Plus Blue Pack - Specifically designed for large dogs
  • Suitable and safe for dogs weighing between 40-60 lbs
  • Offers appropriate dosing (810 mg spinosad and 13.5 mg milbemycin oxime)
  • Beef-flavored tasty chewable tablet for easy and convenient administration
  • Treats and control fleas and intestinal worms (hookworms, roundworms, whipworms)
  • Prevent heartworm disease and control flea allergy dermatitis
  • Available in highly palatable 6 and 12 chews pack sizes
  • Information
  • Features
  • How to Use
  • Safety
  • Comfortis Plus (Trifexis) Ingredients


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Comfortis Plus Blue Pack for Large Dogs 40-60 lbs

Comfortis Plus for large dogs is a #1 vet-recommended flea and worming treatment for large-sized dogs. It is a beef-flavored chewable tablet that efficiently kills fleas and protects against intestinal worms and heartworms. It is a fast-acting flea control treatment as it starts killing fleas within just 30 minutes of administration. This way, it prevents flea infestations and controls flea allergy dermatitis. This reliable treatment also treats and controls intestinal worms like hookworms, roundworms, and whipworms, and prevents the deadly heartworm disease.

Comfortis Plus Blue is recommended for large dogs from eight weeks of age and weighing between 40 and 60lbs (18 and 27 kg).

Comfortis Plus (Spinosad+Milbemycin Oxime) Flea, Worm & Heartworm Treatment

Comfortis Plus is formulated using two powerful treatments: Spinosad and Milbemycin Oxime. Spinosad works on fleas, whereas Milbemycin Oxime works on internal parasites like intestinal worms and heartworms.

Spinosad acts on the nervous system of the fleas, triggering their nerve cells. This leads to involuntary muscle contractions and tremors, which leads to the destruction of fleas. It starts killing fleas within 30 minutes and eliminates 100% of them within 24 hours.

The other active ingredient, Milbemycin Oxime, attacks intestinal worms and immature forms of heartworms. The anthelmintic effectively controls heartworms and intestinal worms protecting the dog from harmful infections.




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  • Advanced version of comfortis with added features
  • New age formula for effectively treating fleas and worms
  • Prevents and controls heartworm infection
  • Starts working on fleas within 30 minutes of administration
  • Treats and prevents worms including hookworm, roundworm, and whipworm
  • Helps in the prevention of flea infestation
  • Supports in the control program of flea allergy dermatitis

How to Use

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  • Dosage depends on dog weight.
  • Administer it directly into the mouth or mix it with food.
  • Ensure the dog finishes the whole food for complete dosage.


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  • Do not use in cats.
  • Keep out of reach of children and other pets.
  • Store it in a cool and dry place.
  • Avoid using on puppies less than 8 weeks of age.
  • Safety in pregnant and lactating dogs has not been evaluated yet.


  • No known side effects found yet.

Comfortis Plus (Trifexis) Ingredients

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  • Spinosad
  • Milbemycin Oxime

Comfortis Plus (Trifexis) Reviews (114)

Product Rated 4.6/5 (114 customer reviews)
Melisha – March 23, 2023
Must buy

I ued this on my frend's recommendation, it's the best treatment.

Grey – March 14, 2023
Thums up

A broad spectrum parasite treatment that treat various species of ticks.

Julie Lane – March 08, 2023

Very effective! We never have flea issues on our dogs or in our house..

Ronnie – February 21, 2023
Works well

Does what it claims fleas are gone and he remains more clams these days.

Linda – February 09, 2023
Value for money

i have been using it for two years never dissapointed.

Theodre – January 31, 2023
Best topical for fleas

My mom bought it for my pets and i am pretty happy with the result.

Railey – November 23, 2022

One treatment treats fleas, ticks and more, my dog is more relazed after monthly treatment.

Terry – November 17, 2022


Sara – November 15, 2022
All in one

This is the first pet product I purchased for my pet, i love how muaj it all works.

Jacob – October 22, 2022

Recommend this do dog parents, works well.