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Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue

167 customer reviews

Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue

$123.12 $87.94

  • $123.12 $87.94
  • $242.10 $172.93

Buy Together - Grab 5% Extra Off

Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue
Heartgard Plus Chewables For Medium Dogs 11-22 kg (25 to 50lbs) Green
Apoquel For Dogs (5.4 mg)
Bravecto For Medium Dogs 10-20kg (22 to 44lbs) Green
Total: $300.94 $285.88
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  • Comfortis Plus Blue Pack - Specifically designed for large dogs
  • Suitable and safe for dogs weighing between 40-60 lbs
  • Offers appropriate dosing (810 mg spinosad and 13.5 mg milbemycin oxime)
  • Beef-flavored tasty chewable tablet for easy and convenient administration
  • Treats and control fleas and intestinal worms (hookworms, roundworms, whipworms)
  • Prevent heartworm disease and control flea allergy dermatitis
  • Available in highly palatable 6 and 12 chews pack sizes
  • Information
  • Features
  • How to Use
  • Safety
  • Comfortis Plus (Trifexis) Ingredients
tab article

Comfortis Plus Blue Pack for Large Dogs 40-60 lbs

Comfortis Plus for large dogs is a #1 vet-recommended flea and worming treatment for large-sized dogs. It is a beef-flavored chewable tablet that efficiently kills fleas and protects against intestinal worms and heartworms. It is a fast-acting flea control treatment as it starts killing fleas within just 30 minutes of administration. This way, it prevents flea infestations and controls flea allergy dermatitis. This reliable treatment also treats and controls intestinal worms like hookworms, roundworms, and whipworms, and prevents the deadly heartworm disease.

Comfortis Plus Blue is recommended for large dogs from eight weeks of age and weighing between 40 and 60lbs (18 and 27 kg).

Comfortis Plus (Spinosad+Milbemycin Oxime) Flea, Worm & Heartworm Treatment

Comfortis Plus is formulated using two powerful treatments: Spinosad and Milbemycin Oxime. Spinosad works on fleas, whereas Milbemycin Oxime works on internal parasites like intestinal worms and heartworms.

Spinosad acts on the nervous system of the fleas, triggering their nerve cells. This leads to involuntary muscle contractions and tremors, which leads to the destruction of fleas. It starts killing fleas within 30 minutes and eliminates 100% of them within 24 hours.

The other active ingredient, Milbemycin Oxime, attacks intestinal worms and immature forms of heartworms. The anthelmintic effectively controls heartworms and intestinal worms protecting the dog from harmful infections.


  • Advanced version of comfortis with added features
  • New age formula for effectively treating fleas and worms
  • Prevents and controls heartworm infection
  • Starts working on fleas within 30 minutes of administration
  • Treats and prevents worms including hookworm, roundworm, and whipworm
  • Helps in the prevention of flea infestation
  • Supports in the control program of flea allergy dermatitis

How to Use

  • Dosage depends on dog weight.
  • Administer it directly into the mouth or mix it with food.
  • Ensure the dog finishes the whole food for complete dosage.


  • Do not use in cats.
  • Keep out of reach of children and other pets.
  • Store it in a cool and dry place.
  • Avoid using on puppies less than 8 weeks of age.
  • Safety in pregnant and lactating dogs has not been evaluated yet.


  • No known side effects found yet.

Comfortis Plus (Trifexis) Ingredients

  • Spinosad
  • Milbemycin Oxime

Comfortis Plus (Trifexis) Reviews (167)

Product Rated 4.7/5 (167 customer reviews)
Ivy Farquhar – February 17, 2024
Dog protection from fleas,ticks,heartworms.

Have used this product for years for all my dogs. Finally found a product that works on the year-round Texas tough fleas. Yahoo Scooby Doo.

Matias – January 31, 2024
Amazing formulation

It has been greatlly formulated that works against all the common range of parasites.

Brian – January 23, 2024
Outstanding results

Kills fleas instantly and provides protection against other parasites as well.

Messiah – January 15, 2024
Best comfort

Provides great comfort to pets by eliminating all the nasty parasites..

Rhett – January 07, 2024
Highly recommended

Protects my furry pals against all the nasty parasites without any discomfort..

Leonel – December 31, 2023
Incredible offers

Couldn't find a better deal than this. I saved more than 15% on a single order!.

Jakob – December 16, 2023
Tasty and effective

My furry boy never refuse to takte this tasty flavored tabs..

Rey – December 15, 2023
Complete proetction

Keeps all the parasites nuisance away with just a single tablet. Would highly recommend to other pet parents like me.

Eliseo – December 07, 2023
Best Shop

I bet you cannot find a better all-in-one parasite treatmnet at this price anywhere else..

Susain – November 30, 2023
Fantastic results

Used for the first time for furry pal and got great results. Will definietly buy this again..