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Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue

Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue

107 customer reviews

$123.12 $87.94

  • $123.12 $87.94
  • $242.10 $172.93

Frequently bought together

Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue
Heartgard Plus Chewables For Medium Dogs 11-22 kg (25 to 50lbs) Green
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Bravecto For Medium Dogs 10-20kg (22 to 44lbs) Green
  • $87.94
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Buy Other Packs

Comfortis Plus (Trifexis) Chewable Tablets for XSmall Dogs 2.3-4.5kg (5 to 10lbs) Pink

$101.37 $72.41

Comfortis Plus (Trifexis) Chewable Tablets for Small Dogs 4.5-9 kg (10 to 20lbs) Orange

$105.49 $75.35

Comfortis Plus (Trifexis) Chewable Tablets for Medium Dogs 9-18 kg (20 to 40lbs) Green

$115.14 $82.24

Comfortis Plus (Trifexis) Chewable Tablets for Xlarge Dogs 27-54 kg (60 to 120lbs) Brown

$128.81 $92.01

Product Review

  • Comfortis Plus Blue Pack - Specifically designed for large dogs
  • Suitable and safe for dogs weighing between 40-60 lbs
  • Offers appropriate dosing (810 mg spinosad and 13.5 mg milbemycin oxime)
  • Beef-flavored tasty chewable tablet for easy and convenient administration
  • Treats and control fleas and intestinal worms (hookworms, roundworms, whipworms)
  • Prevent heartworm disease and control flea allergy dermatitis
  • Available in highly palatable 6 and 12 chews pack sizes

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Comfortis Plus Blue Pack for Large Dogs 40-60 lbs

Comfortis Plus for large dogs is a #1 vet-recommended flea and worming treatment for large-sized dogs. It is a beef-flavored chewable tablet that efficiently kills fleas and protects against intestinal worms and heartworms. It is a fast-acting flea control treatment as it starts killing fleas within just 30 minutes of administration. This way, it prevents flea infestations and controls flea allergy dermatitis. This reliable treatment also treats and controls intestinal worms like hookworms, roundworms, and whipworms, and prevents the deadly heartworm disease.

Comfortis Plus Blue is recommended for large dogs from eight weeks of age and weighing between 40 and 60lbs (18 and 27 kg).

Comfortis Plus (Spinosad+Milbemycin Oxime) Flea, Worm & Heartworm Treatment

Comfortis Plus is formulated using two powerful treatments: Spinosad and Milbemycin Oxime. Spinosad works on fleas, whereas Milbemycin Oxime works on internal parasites like intestinal worms and heartworms.

Spinosad acts on the nervous system of the fleas, triggering their nerve cells. This leads to involuntary muscle contractions and tremors, which leads to the destruction of fleas. It starts killing fleas within 30 minutes and eliminates 100% of them within 24 hours.

The other active ingredient, Milbemycin Oxime, attacks intestinal worms and immature forms of heartworms. The anthelmintic effectively controls heartworms and intestinal worms protecting the dog from harmful infections.



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  • Advanced version of comfortis with added features
  • New age formula for effectively treating fleas and worms
  • Prevents and controls heartworm infection
  • Starts working on fleas within 30 minutes of administration
  • Treats and prevents worms including hookworm, roundworm, and whipworm
  • Helps in the prevention of flea infestation
  • Supports in the control program of flea allergy dermatitis

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  • Dosage depends on dog weight.
  • Administer it directly into the mouth or mix it with food.
  • Ensure the dog finishes the whole food for complete dosage.

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  • Do not use in cats.
  • Keep out of reach of children and other pets.
  • Store it in a cool and dry place.
  • Avoid using on puppies less than 8 weeks of age.
  • Safety in pregnant and lactating dogs has not been evaluated yet.


  • No known side effects found yet.

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  • Spinosad
  • Milbemycin Oxime

Comfortis Plus (Trifexis) Reviews (107)

Product Rated 4.6/5 (107 customer reviews)
Railey – November 23, 2022

One treatment treats fleas, ticks and more, my dog is more relazed after monthly treatment.

Sara – November 15, 2022
All in one

This is the first pet product I purchased for my pet, i love how muaj it all works.

Jacob – October 22, 2022

Recommend this do dog parents, works well.

Mila – October 07, 2022
Wonderful Product

Can see impressive results in just few hours after administration. All fleas down in no time!.

Tony – September 12, 2022

It works, I can result within a day.

Adriel – September 08, 2022

Thank you for keeping my buddy protected..

Dwayne Simonton – August 09, 2022
Comfortis works

This is the only product I buy for my dogs. It just works!.

Bob – August 08, 2022

It is really comforting for pets, recommend.

Jemmie – July 21, 2022
Works well

it started showing results.

Lyn Miller – June 29, 2022
Comfortis Plus

Good product at a good price!.