Use our Online Chat & Save Time.

CALL US NOW: 1-800-797-5305

Earn Reward Points & Get 12% OFF On Your Order, Use Coupon AUTMN12 - Free Shipping On All Orders!

Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue

150 customer reviews

Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue

$123.12 $87.94

  • $123.12 $87.94
  • $242.10 $172.93

Frequently bought together

Comfortis Plus (Trifexis) Chewable Tablets for Large Dogs 18-27 kg (40 to 60 lbs) Blue
Heartgard Plus Chewables For Medium Dogs 11-22 kg (25 to 50lbs) Green
Apoquel For Dogs (5.4 mg)
Bravecto For Medium Dogs 10-20kg (22 to 44lbs) Green
  • $87.94
  • (View Product)
  • (View Product)
  • (View Product)
  • Comfortis Plus Blue Pack - Specifically designed for large dogs
  • Suitable and safe for dogs weighing between 40-60 lbs
  • Offers appropriate dosing (810 mg spinosad and 13.5 mg milbemycin oxime)
  • Beef-flavored tasty chewable tablet for easy and convenient administration
  • Treats and control fleas and intestinal worms (hookworms, roundworms, whipworms)
  • Prevent heartworm disease and control flea allergy dermatitis
  • Available in highly palatable 6 and 12 chews pack sizes
  • Information
  • Features
  • How to Use
  • Safety
  • Comfortis Plus (Trifexis) Ingredients
tab article

Comfortis Plus Blue Pack for Large Dogs 40-60 lbs

Comfortis Plus for large dogs is a #1 vet-recommended flea and worming treatment for large-sized dogs. It is a beef-flavored chewable tablet that efficiently kills fleas and protects against intestinal worms and heartworms. It is a fast-acting flea control treatment as it starts killing fleas within just 30 minutes of administration. This way, it prevents flea infestations and controls flea allergy dermatitis. This reliable treatment also treats and controls intestinal worms like hookworms, roundworms, and whipworms, and prevents the deadly heartworm disease.

Comfortis Plus Blue is recommended for large dogs from eight weeks of age and weighing between 40 and 60lbs (18 and 27 kg).

Comfortis Plus (Spinosad+Milbemycin Oxime) Flea, Worm & Heartworm Treatment

Comfortis Plus is formulated using two powerful treatments: Spinosad and Milbemycin Oxime. Spinosad works on fleas, whereas Milbemycin Oxime works on internal parasites like intestinal worms and heartworms.

Spinosad acts on the nervous system of the fleas, triggering their nerve cells. This leads to involuntary muscle contractions and tremors, which leads to the destruction of fleas. It starts killing fleas within 30 minutes and eliminates 100% of them within 24 hours.

The other active ingredient, Milbemycin Oxime, attacks intestinal worms and immature forms of heartworms. The anthelmintic effectively controls heartworms and intestinal worms protecting the dog from harmful infections.


  • Advanced version of comfortis with added features
  • New age formula for effectively treating fleas and worms
  • Prevents and controls heartworm infection
  • Starts working on fleas within 30 minutes of administration
  • Treats and prevents worms including hookworm, roundworm, and whipworm
  • Helps in the prevention of flea infestation
  • Supports in the control program of flea allergy dermatitis

How to Use

  • Dosage depends on dog weight.
  • Administer it directly into the mouth or mix it with food.
  • Ensure the dog finishes the whole food for complete dosage.


  • Do not use in cats.
  • Keep out of reach of children and other pets.
  • Store it in a cool and dry place.
  • Avoid using on puppies less than 8 weeks of age.
  • Safety in pregnant and lactating dogs has not been evaluated yet.


  • No known side effects found yet.

Comfortis Plus (Trifexis) Ingredients

  • Spinosad
  • Milbemycin Oxime

Comfortis Plus (Trifexis) Reviews (150)

Product Rated 4.7/5 (150 customer reviews)
Eleonoir – September 23, 2023
Always works

I always prefer comfortis over any other brand. It always works for my furry friends and doesn't cause any side effects..

Luz Hegi – September 15, 2023
Comfortis plus

Good product give in the middle of a meal.

Ava – September 15, 2023
My Favorite

Its my goto product for keeping my furry friend parasite-free. Highly recommended.

Ava – September 15, 2023
My Favorite

Its my goto product for keeping my furry friend parasite-free. Highly recommended.

Sandra – September 07, 2023

Easy to administer and effective for all the common external parasites. Would highly recommend this.

Marle – August 31, 2023
Works great

Single chew works amazing for all the parasites. Would highly recommned this.

Steve Kadlec – August 27, 2023
Comfortis Plus for dogs

We've used comfortis for 6 years. It's the best flea preventative We've found. Budgetvetcare is one of the best online supply pet store that We have found!.

Silver – August 24, 2023

Safe and trustworthy product for my pet..

Leo – August 16, 2023

Quick delivery and very good customer care..

Harry – August 08, 2023

The shipping was super-fast! Thank you!.