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Comfortis Plus (Trifexis) for Dog

(177 customer reviews)
You Pay
6 Chews
12 Chews
You Pay
6 Chews
12 Chews
You Pay
6 Chews
12 Chews
You Pay
6 Chews
12 Chews
You Pay
6 Chews
12 Chews
  • All-in-one treatment for fleas, worms, and heartworms in dogs
  • Easy-to-dose highly-palatable tablet
  • Once-a-month administration
  • Kills 100% fleas within 24 hours and prevents further infestations
  • Treats flea allergy dermatitis
  • Treats intestinal worms like hookworms, roundworms, and whipworms
  • Prevents deadly heartworm disease
  • Information
  • Features
  • How to Use
  • Safety
  • Comfortis Plus (Trifexis) Ingredients
tab article

Comfortis Plus – Fleas, Worms, and Heartworm Protection

Comfortis Plus is an advanced formulation that provides 3-in-1 protection against fleas, worms, and heartworms in dogs. The monthly oral tablet controls heartworms and protects dogs against the deadly heartworm disease. It kills fleas within 24 hours and controls and prevents flea infestations. The oral tablet is also effective in treating intestinal worms, including hookworms, roundworms, and whipworms. Furthermore, Comfortis Plus also aids in the control of flea allergy dermatitis.

It is recommended for use in dogs and puppies from eight weeks of age weighing 5 lbs or greater.

How Dose Comfortis Plus for Dogs Work?

Comfortis Plus contains two active insecticides: Spinosad and Milbemycin Oxime. Spinosad is an effective insecticide with no negative effects on the environment. The ingredient acts on the nervous system of fleas, triggering their nerve cells. This leads to involuntary muscle contractions and tremors, which lead to the destruction of the fleas. It starts killing fleas within 30 minutes and eliminates 100% of them within 24 hours.

The other active ingredient, Milbemycin Oxime, attacks intestinal worms and immature forms of heartworms. The anthelmintic effectively controls heartworms and intestinal worms, protecting the dog from harmful infections.


  • Advanced version of comfortis with added features
  • New age formula for effectively treating fleas and worms
  • Prevents and controls heartworm infection
  • Starts working on fleas within 30 minutes of administration
  • Treats and prevents worms including hookworm, roundworm, and whipworm
  • Helps in the prevention of flea infestation
  • Supports in the control program of flea allergy dermatitis

How to Use

  • Dosage depends on dog weight.
  • Administer it directly into the mouth or mix it with food.
  • Ensure the dog finishes the whole food for complete dosage.


  • Do not use in cats.
  • Keep out of reach of children and other pets.
  • Store it in a cool and dry place.
  • Avoid using on puppies less than 8 weeks of age.
  • Safety in pregnant and lactating dogs has not been evaluated yet.


  • No known side effects found yet.

Comfortis Plus (Trifexis) Ingredients

  • Spinosad
  • Milbemycin Oxime

Comfortis Plus (Trifexis) Reviews (177)

Product Rated 4.7/5 (177 customer reviews)
Kelley Gray – March 25, 2024

As a dog rescue I appreciate you guys so much your products are a great price your customer service is awesome I tell everybody about you.

August – March 25, 2024

Found the best price, the lowest on the market!.

Aryan – March 23, 2024
Value for money

The website offers low prices and reliable delivery.

Stanley – March 15, 2024

Great prices for all the brand-name products. Lowest prices I have ever seen for such products..

Nicola Devine – March 09, 2024
Free of flees

We love it!!.

Callan – March 07, 2024
Best Treatment

The best and effective treatment I have ever used for my pal..

Louis – February 29, 2024
Best Med

Keeps my furry champs parasite-free, healthy and happy!.

Joanne – February 23, 2024
Impressive treatment

Bought this for flea control and it worked! Thanks!.

Ivy Farquhar – February 17, 2024
Dog protection from fleas,ticks,heartworms.

Have used this product for years for all my dogs. Finally found a product that works on the year-round Texas tough fleas. Yahoo Scooby Doo.

Olive – February 15, 2024
Wonderful protection

No more extra tabs and solutions for protecting my pals against those nasty parasites. This has the potential of controlling all the pests in single chew..