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Comfortis Plus (Trifexis) for Dog

(189 customer reviews)
You Pay
6 Chews
12 Chews
You Pay
6 Chews
12 Chews
You Pay
6 Chews
12 Chews
You Pay
6 Chews
12 Chews
  • All-in-one treatment for fleas, worms, and heartworms in dogs
  • Easy-to-dose highly-palatable tablet
  • Once-a-month administration
  • Kills 100% fleas within 24 hours and prevents further infestations
  • Treats flea allergy dermatitis
  • Treats intestinal worms like hookworms, roundworms, and whipworms
  • Prevents deadly heartworm disease
  • Information
  • Features
  • How to Use
  • Safety
  • Comfortis Plus (Trifexis) Ingredients
tab article

Comfortis Plus – Fleas, Worms, and Heartworm Protection

Comfortis Plus is an advanced formulation that provides 3-in-1 protection against fleas, worms, and heartworms in dogs. The monthly oral tablet controls heartworms and protects dogs against the deadly heartworm disease. It kills fleas within 24 hours and controls and prevents flea infestations. The oral tablet is also effective in treating intestinal worms, including hookworms, roundworms, and whipworms. Furthermore, Comfortis Plus also aids in the control of flea allergy dermatitis.

It is recommended for use in dogs and puppies from eight weeks of age weighing 5 lbs or greater.

How Dose Comfortis Plus for Dogs Work?

Comfortis Plus contains two active insecticides: Spinosad and Milbemycin Oxime. Spinosad is an effective insecticide with no negative effects on the environment. The ingredient acts on the nervous system of fleas, triggering their nerve cells. This leads to involuntary muscle contractions and tremors, which lead to the destruction of the fleas. It starts killing fleas within 30 minutes and eliminates 100% of them within 24 hours.

The other active ingredient, Milbemycin Oxime, attacks intestinal worms and immature forms of heartworms. The anthelmintic effectively controls heartworms and intestinal worms, protecting the dog from harmful infections.


  • Advanced version of comfortis with added features
  • New age formula for effectively treating fleas and worms
  • Prevents and controls heartworm infection
  • Starts working on fleas within 30 minutes of administration
  • Treats and prevents worms including hookworm, roundworm, and whipworm
  • Helps in the prevention of flea infestation
  • Supports in the control program of flea allergy dermatitis

How to Use

  • Dosage depends on dog weight.
  • Administer it directly into the mouth or mix it with food.
  • Ensure the dog finishes the whole food for complete dosage.


  • Do not use in cats.
  • Keep out of reach of children and other pets.
  • Store it in a cool and dry place.
  • Avoid using on puppies less than 8 weeks of age.
  • Safety in pregnant and lactating dogs has not been evaluated yet.


  • No known side effects found yet.

Comfortis Plus (Trifexis) Ingredients

  • Spinosad
  • Milbemycin Oxime

Comfortis Plus (Trifexis) Reviews (189)

Product Rated 4.7/5 (189 customer reviews)
Brian McInnis – June 15, 2024

So far I"m pleased with the Comfortis - my dogs just took it today. I was pleased with the price after the discounts were applied and I will purchase this product from Budget Vetcare again if my price remains the same. Thank you!.

Kenneth – June 09, 2024
Kills fleas and worms

Single product to get rid of both fleas and worms from my pet..

Betty – June 03, 2024
Fleas are gone quickly

It removes all fleas in just few hours. Best for my pet..

Herbert – May 27, 2024
Heartworms no more

It is one of the best ways to keep my pet protected from heartworms..

Dan McCallum – May 23, 2024

always great prices and good delivery.

Edward – May 21, 2024
Quick action

It removes fleas from my pet in a matter of hours. Superb product..

George – May 14, 2024
Super quick results

The dose works fast. It gives quick relief to my buddy from flea bites and worms problem..

Nick – May 07, 2024
Nice wormer

It removes multiple types of worms with ease..

Zander – April 30, 2024
Worthy Product

It works exactly what it labels says!.

Benicio – April 23, 2024
Great product

Provides the necessary care and protection against parasites without causing any trouble or discomfort to my pets..