Simparica Trio vs. Credelio and Interceptor Plus: Ideal Broad-Spectrum Protection?
When it comes to finalizing a suitable treatment for protecting dogs against parasites, dog parents have to face a myriad of options in the market. Moving past that, there’s another predicament: not all the treatments cover both internal and external parasites. In such cases, many vets suggest putting two treatments together to provide comprehensive protection.
In this blog, we’ll put one such combination against a broad-spectrum treatment and see how it turns out. This is a side-by-side comparison between Simparica Trio and Credelio + Interceptor Plus. We’ll explore the fundamentals, effectiveness, similarities, and differences of these treatments to equip you with the right knowledge to make an informed decision.
Ready with your notepads? Let’s go!
Product Overview: Understanding the Treatments
Let’s take a quick stroll through the fundamentals of these treatments before taking a deep dive into their differences and similarities.
Simparica Trio
Simparica Trio is a broad-spectrum treatment formulated with Sarolaner, Moxidectin, and pyrantel as active ingredients to protect dogs against internal and external parasites. Suitable for dogs and puppies from 8 weeks of age, weighing at least 2.8 lbs, these chewable tablets:
- kill adult fleas and treat and prevent flea infestations.
- indicated for the prevention of heartworm disease.
- Recommended for the prevention of Lyme disease.
- Treat and control roundworm and hookworm infections.
- Treat and control infestations caused by various tick species, including lone star ticks, Gulf Coast ticks, American dog ticks, black-legged ticks, Asian long-horned ticks, and brown dog ticks.
Explore more about: Simparica Trio- All Together Treatment For Dogs
Credelio + Interceptor Plus
Giving Credelio and Interceptor Plus together will provide 360-degree protection to dogs. Let’s learn more about these treatments:
Credelio for dogs
Credelio is a monthly oral treatment formulated with lotilaner as the active ingredient to protect dogs against fleas and ticks. These beef-flavored chewable tablets are suitable for dogs and puppies from 8 weeks of age, weighing at least 4.4 lbs. Each chew:
- kills adult fleas and is indicated for the treatment and prevention of flea infestations.
- helps soothe symptoms of flea allergy dermatitis.
- Begins killing fleas within 4 hours after administration or infestation.
- Treats and controls infestations of lone star ticks, American dog ticks, black-legged ticks, and brown dog ticks.
Interceptor Plus
Interceptor Plus is a monthly oral chew designed to protect dogs and puppies from 6 weeks of age against intestinal worms and heartworm disease. These chicken-flavored chews contain Milbemycin Oxime and Praziquantel as active ingredients and:
- Treat and control infections of roundworms, hookworms, whipworms, and tapeworms.
- Aids in the prevention of heartworm disease caused by Dirofilaria Immitis.
Side-by-Side Comparison: Simparica Trio vs. Credelio +Interceptor Plus
Now that you have more information about each treatment, let’s put them against each other and observe the differences and similarities.

Which One to Go with?
Simparica Trio offers a wide range of protection, while the combination of Credelio and Interceptor Plus back each other to provide comprehensive protection. They offer similar protection with only minor differences in worm and tick species:
Interceptor Plus covers Whipworms and tapeworms, which Simparica Trio does not. On the other hand, Simparica Trio covers lone star ticks and Asian long-horned ticks, which Credelio does not cover.
So which one should you select? Well, it boils down to your convenience and your pet’s preference. If you select the combination of Credelio and Interceptor Plus, you may have to train your dog to take two treatments. But it won’t be much of a hassle, as both are flavored chews. On the other hand, if you go with Simparica Trio, there will be just one treatment to give.
However, if you’re still confused, it’s best to consult your vet. They will suggest the treatment option best suited for your dog depending on their condition and medical history. Plus, they’ll ensure whether the combination treatment is suitable for them or not.